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Active/Inactive Dual‐Probe System for Selective Photoaffinity Labeling of Small Molecule‐Binding Proteins
Author(s) -
Sakurai Kaori,
Tawa Masaki,
Okada Ayumi,
Yamada Rika,
Sato Noriyuki,
Inahara Masahiro,
Inoue Maia
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200085
Subject(s) - photoaffinity labeling , small molecule , chemistry , computer science , affinity label , computational biology , combinatorial chemistry , biochemistry , binding site , biology
Two are better than one : A new approach to selective photoaffinity labeling is described in which a bioactive probe is used in combination with its inactive analog as a scavenger of nonspecific proteins.