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Asymmetric Calcium Catalysis : Highly Enantioselective Carbonyl‐Ene and Friedel–Crafts Reactions for the Synthesis of Quaternary α‐Hydroxy Esters Bearing a Trifluoromethyl Group
Author(s) -
Rueping Magnus,
Bootwicha Teerawut,
Kambutong Supakeat,
Sugiono Erli
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200063
Subject(s) - enantioselective synthesis , chemistry , catalysis , friedel–crafts reaction , trifluoromethyl , ene reaction , organic chemistry , indole test , styrene , copolymer , alkyl , polymer
Enantioselective calcium‐catalyzed addition reactions of styrene and indole derivatives with trifluoropyruvates have been developed. The alkaline‐earth metal‐catalyzed reactions proceed smoothly to afford the corresponding products in high yields and with good to excellent enantioselectivities under mild reaction conditions.