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Amide‐Directed Tandem CC/CN Bond Formation through CH Activation
Author(s) -
Zhu Chen,
Wang Rui,
Falck John R.
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200035
Subject(s) - amide , chemistry , tandem , peptide bond , stereochemistry , nitrogen atom , group (periodic table) , organic chemistry , materials science , composite material , enzyme
The transformation of CH bonds into other chemical bonds is of great significance in synthetic chemistry. CH bond‐activation processes provide a straightforward and atom‐economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of CH activation, the amide group not only offers excellent regiodirecting ability, but is also a potential CN bond precursor. As a consequence, a variety of nitrogen‐containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide‐directed tandem CC/CN bond‐formation process through CH activation. The large body of research in this field over the past three years has established it as one of the most‐important topics in organic chemistry.