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Highly Efficient Asymmetric Michael Addition of Diaryl Phosphine Oxides to α,β‐Unsaturated N‐Acylated Oxazolidin‐2‐ones
Author(s) -
Zhao Depeng,
Wang Linqing,
Yang Dongxu,
Zhang Yixin,
Wang Rui
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200025
Subject(s) - phosphine , michael reaction , scope (computer science) , denticity , substrate (aquarium) , phosphine oxide , chemistry , combinatorial chemistry , organic chemistry , computer science , programming language , catalysis , biology , ecology , crystal structure
A highly efficient asymmetric Michael reaction of diaryl phosphine oxides with α,β‐unsaturated N‐acylated oxazolidinones has been developed. Excellent enantioselectivities (up to >99 % ee ) and chemical yields (up to 99 %) were achieved with a broad substrate scope of the oxazolidinones. The bidentate property of oxazolidinones was found to be critical for high enantioselectivities.