Premium
Aerobic Amide Bond Formation with N ‐hydroxysuccinimide
Author(s) -
Yao Haoyi,
Yamamoto Kana
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201200017
Subject(s) - amide , catalysis , chemistry , molecular oxygen , oxidative phosphorylation , peptide bond , oxygen atom , combinatorial chemistry , polymer chemistry , organic chemistry , molecule , biochemistry , enzyme
Breathe easy : Molecular oxygen is one of the most abundant, atom‐efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) 2 and N ‐hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.