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Inside Cover: Click to Join Peptides/Proteins Together (Chem. Asian J. 10/2011)
Author(s) -
Li Xuechen
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201190041
Subject(s) - click chemistry , cycloaddition , moiety , azide , peptide , regioselectivity , combinatorial chemistry , chemistry , triazole , stereochemistry , organic chemistry , biochemistry , catalysis
Click to Ligate Copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) represents a high‐yielding, chemoselective, regioselective, bio‐orthogonal, and easy‐to‐perform reaction. In addition, the resultant triazole moiety resembles the natural peptide bond in many aspects. In the Focus Review on page 2606 ff, X. Li has reviewed and discussed the advancement of CuAAC reactions in peptide/protein ligation. The application of click chemistry in synthetic protein chemistry is still at an early stage; nevertheless it is an exciting and promising research area for explorations.