Premium
Catalytic Arylation of a CH Bond in Pyridine and Related Six‐Membered N‐Heteroarenes Using Organozinc Reagents
Author(s) -
Hyodo Isao,
Tobisu Mamoru,
Chatani Naoto
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100971
Subject(s) - pyridine , chemistry , catalysis , pyrazine , reagent , nucleophile , electrophile , combinatorial chemistry , medicinal chemistry , organic chemistry
Despite significant advances in the catalytic direct arylation of heteroarenes, the application of this reaction to pyridines has been met with limited success. An oxidative nucleophilic arylation strategy has been developed to overcome this problem. Pyridine, pyrazine, quinolone, and related electron‐deficient N‐heteroarenes can be arylated at the most electrophilic site using the developed nickel‐catalyzed reaction. This protocol serves as a complementary method to catalytic direct arylation reactions .