Synthesis of 2′‐Deoxy‐5‐(methylselenyl)cytidine and Se‐DNAs for Structural and Functional Studies | Zendy

Zhang Wen | Zendy; Sheng Jia | Zendy; Hassan Abdalla E. | Zendy; Huang Zhen | Zendy

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Synthesis of 2′‐Deoxy‐5‐(methylselenyl)cytidine and Se‐DNAs for Structural and Functional Studies

Author(s) -

Zhang Wen,

Sheng Jia,

Hassan Abdalla E.,

Huang Zhen

Publication year - 2012

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201100898

Subject(s) - cytidine , phosphoramidite , deoxycytidine , chemistry , methylation , dna , dna synthesis , stereochemistry , combinatorial chemistry , biochemistry , oligonucleotide , biology , genetics , enzyme , chemotherapy , gemcitabine

It's not in your DNA : We report here the synthesis of a novel 5‐methyl deoxycytidine analog and its phosphoramidite modified with selenium at the C‐5 position ( Se C). Incorporation of Se C into DNA does not cause structural perturbations, as shown by X‐ray crystallography and in agreement with UV melting data. The Se modification provides a useful strategy for biochemical and structural investigations on 5‐methylation of cytidine.

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