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Advantages and Potential of Lipid‐Membrane‐Incorporating Fullerenes Prepared by the Fullerene‐Exchange Method
Author(s) -
Ikeda Atsushi,
Mori Miyuki,
Kiguchi Kazuya,
Yasuhara Kazuma,
Kikuchi Junichi,
Nobusawa Kazuyuki,
Akiyama Motofusa,
Hashizume Mineo,
Ogawa Takuya,
Takeya Tatsuo
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100792
Subject(s) - fullerene , chloroform , chemistry , dissolution , liposome , chromatography , extraction (chemistry) , vesicle , membrane , organic chemistry , biochemistry
Lipid‐membrane‐incorporating C 60 and C 70 (LMIC 60 and LMIC 70 ) were prepared by the fullerene‐exchange reaction from the γ‐cyclodextrin cavity to vesicles (we call this method the “exchange method”). An advantage of this method is that the ratios of [C 60 ]/[lipids] and [C 70 ]/[lipids] can be arbitrarily controlled by adjusting the ratios of the fullerenes and liposome. The maximum ratio (30 mol %) obtained was approximately 14 and 100 times higher than those achieved for LMIC 60 and LMIC 70 , respectively, that were prepared by the classical method, which we call the “premixing method” (dissolving lipids and C 60 or C 70 in chloroform, followed by concentration and extraction with water). Furthermore, the stabilities and photodynamic activities of the LMIC 60 and LMIC 70 solutions prepared by the exchange method were shown to be much higher than those prepared by the premixing method. That is, the exchange method was found to be superior to the premixing method as a preparative method of LMIC 60 and LMIC 70 for applications in photomedical and photomaterials chemistry.