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Microwave‐Promoted “One‐Pot” Synthesis of 4‐Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor
Author(s) -
Niu HongYing,
Xia Chao,
Qu GuiRong,
Wu Shan,
Jiang Yi,
Jin Xin,
Guo HaiMing
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100699
Subject(s) - thiourea , sulfur , scope (computer science) , microwave irradiation , purine , chemistry , combinatorial chemistry , microwave , computer science , process (computing) , catalysis , process engineering , organic chemistry , engineering , telecommunications , programming language , enzyme
An efficient one‐pot method for the synthesis of various C6‐alkylthio‐substituted purine nucleosides has been developed under microwave irradiation with good to excellent yields without any metal catalyst (see scheme). This process expands the scope of existing synthetic methodologies and was further successfully applied for synthesis of the biologically important compound 4‐nitrobenzylthioinosine (NBTI).