Premium
Induced Circular‐Dichroism Chirality Probes for Selective Amino Acid Detection through Screening of a Dynamic Combinatorial Library of Lanthanide Complexes
Author(s) -
Shinoda Satoshi,
Terada Keiko,
Tsukube Hiroshi
Publication year - 2012
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100618
Subject(s) - lanthanide , chirality (physics) , circular dichroism , chemistry , chromophore , stereochemistry , amino acid , selectivity , amine gas treating , combinatorial chemistry , photochemistry , organic chemistry , catalysis , biochemistry , ion , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
A dynamic combinatorial library of lanthanide complexes was prepared to develop induced‐circular‐dichroism (CD) chirality probes. It totaled 168 combinations of coordinative N‐aromatic chromophores, trivalent lanthanide centers, and guest amino acids. Eu 3+ and Tb 3+ complexes prepared with quinolinecarboxylic acid were particularly effective as induced‐CD chirality probes for selective alanine detection, whereas a Yb 3+ complex with terpyridine exhibited glutamine selectivity. The former two complexes highly preferred alanine to the corresponding amine, ester, amino alcohol, and carboxylic acid derivatives. As such, the present combinatorial screening of a dynamic lanthanide complex library has led to a new series of induced‐CD chirality probes for specific amino acids.