Synthesis of Optically Active  N ‐Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy–Thiourea Catalyst | Zendy

Inokuma Tsubasa | Zendy; Suzuki Yusuke | Zendy; Sakaeda Toshiyuki | Zendy; Takemoto Yoshiji | Zendy

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Synthesis of Optically Active N ‐Aryl Amino Acid Derivatives through the Asymmetric Petasis Reaction Catalyzed by a Novel Hydroxy–Thiourea Catalyst

Author(s) -

Inokuma Tsubasa,

Suzuki Yusuke,

Sakaeda Toshiyuki,

Takemoto Yoshiji

Publication year - 2011

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201100453

Subject(s) - thiourea , yield (engineering) , catalysis , chemistry , aryl , combinatorial chemistry , monomer , amino acid , optically active , organic chemistry , materials science , biochemistry , polymer , alkyl , metallurgy

Thiourea makes peptides : Asymmetric Petasis reactions with vinylboronates and α‐iminoamides are effectively catalyzed by the novel hydroxy–thiourea catalyst 1 (up to 86 % yield, 93 % ee ; see scheme). This reaction can be applied not only to the synthesis of the unnatural amino acid monomers but also to peptide oligomers.

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