Premium
Internal Chelation‐Guided Regio‐ and Stereoselective Pauson–Khand‐Type Reaction by Chiral Rhodium(I) Catalysis
Author(s) -
Kim Dong Eun,
Park Sang Hee,
Choi Yun Hee,
Lee SuegGeun,
Moon Dohyun,
Seo Jungju,
Jeong Nakcheol
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100271
Subject(s) - stereoselectivity , reactivity (psychology) , chelation , rhodium , chemistry , catalysis , substrate (aquarium) , oxygen atom , stereochemistry , combinatorial chemistry , organic chemistry , molecule , biology , medicine , ecology , alternative medicine , pathology
Touch, Pauson, engage : To explain the unique superior reactivity and stereoselectivity of O ‐tethered enynes in asymmetric Pauson–Khand type reaction (APKR) than their congeners, the internal‐chelation to metal of oxygen atom of the substrate in the transition state was proposed. This proposition was well supported by APKR with several different substrates.