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Base‐Free Palladium‐Catalyzed Sonogashira Coupling Using Organogold Complexes
Author(s) -
Pankajakshan Sreekumar,
Loh TeckPeng
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100263
Subject(s) - sonogashira coupling , palladium , aryl , chemistry , catalysis , combinatorial chemistry , nucleophile , base (topology) , coupling (piping) , organic chemistry , materials science , mathematics , metallurgy , mathematical analysis , alkyl
Turn to gold : An effective protocol for base‐free Sonogashira coupling reactions using organogold complexes as nucleophilic partners has been developed. The palladium‐catalyzed methodology offers a general synthesis of aryl–alkynes under operationally simple conditions in good to excellent yields.