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Divergent and Site‐Selective Solid‐Phase Synthesis of Sulfopeptides
Author(s) -
Taleski Deni,
Butler Stephen J.,
Stone Martin J.,
Payne Richard J.
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100232
Subject(s) - solid phase synthesis , sulfation , computer science , phase (matter) , combinatorial chemistry , information retrieval , computational biology , chemistry , biology , biochemistry , organic chemistry , peptide
On solid ground : A solid‐phase strategy for the efficient synthesis of sulfopeptides is described. Selective deprotection of orthogonally‐protected tyrosine residues and solid‐phase sulfation provided divergent access to differentially sulfated peptides in high yields.