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Oxyfold: A Simple and Efficient Solid‐Supported Reagent for Disulfide Bond Formation
Author(s) -
Verdié Pascal,
Ronga Luisa,
Cristau Michèle,
Amblard Muriel,
Cantel Sonia,
Enjalbal Christine,
Puget Karine,
Martinez Jean,
Subra Gilles
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100202
Subject(s) - reagent , disulfide bond , polymerization , polymer , combinatorial chemistry , chemistry , simple (philosophy) , polymer chemistry , organic chemistry , biochemistry , philosophy , epistemology
The synthesis and use of novel polymer‐supported reagents for disulfide bond formation is described. This family of supported reagents consists of a series of oxidized methionines grafted onto a solid support. Their cost and the simplicity of their preparation through N ‐carboxyanhydride polymerization on beads make them reactants of choice for the formation of disulfide bridges in peptides.