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Encapsulation of Pyrene‐Functionalized Poly(benzyl ether) Dendrons into a Water‐Soluble Organometallic Cage
Author(s) -
PittoBarry Anaïs,
Barry Nicolas P. E.,
Zava Olivier,
Deschenaux Robert,
Therrien Bruno
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100136
Subject(s) - dendrimer , pyrene , chemistry , ether , ruthenium , triazine , molecule , polymer chemistry , cytotoxicity , combinatorial chemistry , organic chemistry , catalysis , biochemistry , in vitro
Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P 1 and P 2 ) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules encapsulated in the arene–ruthenium metalla‐cage, [Ru 6 ( p ‐cymene) 6 (tpt) 2 (donq) 3 ] 6+ ([ 1 ] 6+ ) (tpt=2,4,6‐tri(pyridin‐4‐yl)‐1,3,5‐triazine; donq=5,8‐dioxydo‐1,4‐naphthoquinonato). The host–guest properties of [P 1 ⊂ 1 ] 6+ and [P 2 ⊂ 1 ] 6+ were studied in solution by NMR and UV/Vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water‐soluble host–guest systems was evaluated on human ovarian cancer cells.