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Small Mesoporous Silica Nanoparticles as Carriers for Enhanced Photodynamic Therapy
Author(s) -
Zhu Jie,
Wang Huixiang,
Liao Lei,
Zhao Lingzhi,
Zhou Liang,
Yu Meihua,
Wang Yunhua,
Liu Baohong,
Yu Chengzhong
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100064
Subject(s) - mesoporous silica , photodynamic therapy , photosensitizer , nanoparticle , endocytosis , mesoporous material , cytotoxicity , materials science , nanotechnology , cancer therapy , cancer cell , cancer , chemistry , biophysics , photochemistry , organic chemistry , medicine , cell , catalysis , biochemistry , in vitro , biology
Abstract Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl 2 (82.6 % in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl 2 being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl 2 at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti‐cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs.