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Pd‐Catalyzed Sequential CC and CN Bond Formations for the Synthesis of N‐Heterocycles: Exploiting Protecting Group‐Directed CH Activation under Modified Reaction Conditions
Author(s) -
Kim Byung Seok,
Lee Sun Young,
Youn So Won
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201100024
Subject(s) - chemistry , rendering (computer graphics) , conjugate , catalysis , cascade reaction , functional group , combinatorial chemistry , domino , protecting group , stereochemistry , medicinal chemistry , organic chemistry , mathematics , computer science , mathematical analysis , polymer , computer graphics (images) , alkyl
Easy & efficient : A Pd‐catalyzed domino olefination/conjugate addition reaction of N ‐Ts‐2‐arylanilines with activated olefins has been achieved at ambient temperature under the newly defined reaction conditions. This process highlighted the directing effect of the N‐protecting group in CH activation, displayed broad substrate scope with wide functional group compatibility; thus rendering a straightforward entry to a wide variety of N‐heterocycles such as dihydrophenanthridines.