Premium
Cover Picture: Iron‐Catalyzed Carbonylation as a Key Step in the Short and Efficient Syntheses of Himanimide A and B (Chem. Asian J. 10/2010)
Author(s) -
Prateeptongkum Saisuree,
Driller Katrin Marie,
Jackstell Ralf,
Beller Matthias
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201090033
Subject(s) - annulation , carbonylation , yield (engineering) , catalysis , chemistry , combinatorial chemistry , cover (algebra) , organic chemistry , materials science , engineering , mechanical engineering , carbon monoxide , metallurgy
An iron–catalyzed [2+1+1+1]–annulation strategy was used for the construction of five–membered maleimides, which are building blocks for naturally occurring himanimides A and B. In their Communication on page 2173 ff., M. Beller et al. report that the syntheses of himanimide A and B are conveniently achieved in only 4 and 5 steps from commercially available starting materials, respectively. Whilst himanimide B was prepared for the first time, the synthesis of himanimide A has been significantly improved with respect to overall yield. This synthetic strategy can be applied to other related bio–active compounds, such as camphorataimides, antrocinnamomins, polycitrins, and arcyriarubins.