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Cover Picture: Total Synthesis Confirms Laetirobin as a Formal Diels–Alder Adduct (Chem. Asian J. 2/2010)
Author(s) -
Simon Oliver,
Reux Bastien,
La Clair James J.,
Lear Martin J.
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201090000
Subject(s) - fungus , adduct , natural product , mitosis , diels–alder reaction , apoptosis , stereochemistry , total synthesis , cover (algebra) , chemistry , division (mathematics) , yield (engineering) , programmed cell death , biology , botany , organic chemistry , microbiology and biotechnology , biochemistry , catalysis , arithmetic , mathematics , physics , engineering , mechanical engineering , thermodynamics
Natural product laetirobin, isolated from a parasitic fungus host–plant relationship, is synthesized in six practical steps with an overall yield of 12 % from commercially available 2,4‐dihydroxyacetophenone. M. J. Lear et al. provide preliminary structure–activity relationship data between the isomeric [4+2] and [5+2] tetramers that reveal that only the natural product possesses promising anticancer potential. Specifically, laetirobin is capable of blocking tumor cell division (mitosis) and invoking programmed cell death (apoptosis). For further details, turn to their Full Paper on page 342 ff .