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One‐Pot Nitrile Aldolization/Hydration Operation Giving β‐Hydroxy Carboxamides
Author(s) -
Goto Akihiro,
Naka Hiroshi,
Noyori Ryoji,
Saito Susumu
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000921
Subject(s) - nitrile , aldol reaction , catalysis , chemistry , organic chemistry , alkyl , rhodium , combinatorial chemistry
Rhodium to the rescue : The formal aldol products of carboxamides (CONH 2 ) were obtained by using a Rh I (OR) (R=H, Me) catalyst under essentially neutral pH and ambient conditions. This novel aldol strategy is based on the catalytic aldol‐type reaction of nitriles, followed by hydration of the nitrile functionality (R 1 =aromatic or aliphatic, R 2 and R 3 =H or alkyl; see scheme).
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