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Enzyme‐Responsive Multifunctional Magnetic Nanoparticles for Tumor Intracellular Drug Delivery and Imaging
Author(s) -
Yang Yanmei,
Aw Junxin,
Chen Kai,
Liu Fang,
Padmanabhan Parasuraman,
Hou Yanglong,
Cheng Zhen,
Xing Bengang
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000905
Subject(s) - intracellular , conjugate , drug delivery , doxorubicin , conjugated system , enzyme , nanoparticle , cytotoxicity , click chemistry , cathepsin b , biophysics , chemistry , covalent bond , targeted drug delivery , magnetic nanoparticles , in vitro , nanotechnology , materials science , biochemistry , combinatorial chemistry , polymer , biology , organic chemistry , chemotherapy , mathematical analysis , mathematics , genetics
Enzyme‐responsive, hybrid, magnetic silica nanoparticles have been employed for multifunctional applications in selective drug delivery and intracellular tumor imaging. In this study, doxorubicin (Dox)‐conjugated, enzyme‐cleavable peptide precursors were covalently tethered onto the surface of uniform silica‐coated magnetic nanoparticles through click chemistry. This enzyme‐responsive nanoparticle conjugate demonstrated highly efficient Dox release upon specific enzyme interactions in vitro. It also exhibits multiple functions in selective tumor intracellular drug delivery and imaging in the tumor cells with high cathepsin B expression, whereas it exhibited lower cytotoxicity towards other cells without enzyme expression.