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Gold Nanoparticles Carrying Diatomic Molecules (O 2 and CO) in Aqueous Solution
Author(s) -
Karasugi Keiichi,
Kitagishi Hiroaki,
Kano Koji
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000756
Subject(s) - chemistry , aqueous solution , dimer , ethylene glycol , colloidal gold , nuclear chemistry , ferric , molecule , pyridine , inorganic chemistry , monomer , nanoparticle , medicinal chemistry , organic chemistry , materials science , nanotechnology , polymer
Gold nanoparticles (AuNPs) prepared by citrate reduction of aurochloric acid (HAuCl 4 ) were functionalized by tris(4‐sulfonatophenyl)porphinatoiron(III) (Fe III P2) and poly(ethylene glycol) with thiolated arms (PEG‐SH). Fe III P2 on the AuNP surface existed as its μ‐oxo dimer, which was reduced by Na 2 S 2 O 4 to yield monomeric Fe II P2. Fe II P2‐bearing AuNPs were further functionalized through inclusion of two sulfonatophenyl groups of Fe II P2 by a per‐ O ‐methylated β‐cyclodextrin dimer with a pyridine linker (Py3CD) to obtain AuNPs capable of carrying diatomic molecules in the body. The resulting AuNPs (hemoCD‐AuNPs) bound O 2 as well as CO in an aqueous solution. Although a noncolloidal 1:1 complex of 5,10,15,20‐tetrakis(4‐sulfonatophenyl)porphinatoiron(II) and Py3CD injected into the femoral vein of a rat was rapidly excreted in the urine, no excretion was observed with ferric hemoCD‐AuNPs, which were gradually accumulated in the spleen and liver of a rat. These results suggest that hemoCD‐AuNPs can be used as a carrier of diatomic molecules such as O 2 and CO in vivo.