Premium
A General Strategy for the Introduction of Stereogenic Centers Bearing a Methyl Group: Total Synthesis of Sex Pheromones
Author(s) -
Wang ShunYi,
Song Ping,
Chin YenJin,
Loh TeckPeng
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000663
Subject(s) - stereocenter , sex pheromone , conjugate , group (periodic table) , computer science , mathematics , biology , botany , chemistry , organic chemistry , enantioselective synthesis , mathematical analysis , catalysis
We're bringing sexy back : The highly efficient introduction of stereogenic centers bearing methyl group by conjugate addition of RMgBr to α,β‐unsaturated esters has been employed in the total syntheses of two sex pheromones (see scheme). Binap=[1,1′‐binaphthalene]‐2,2′‐diylbis(diphenylphosphane).