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Total Synthesis of Dictyodendrins A–E
Author(s) -
Tokuyama Hidetoshi,
Okano Kentaro,
Fujiwara Hideto,
Noji Toshiharu,
Fukuyama Tohru
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000544
Subject(s) - indoline , aryne , total synthesis , sequence (biology) , modular design , stereochemistry , key (lock) , chemistry , computer science , medicinal chemistry , operating system , biochemistry
A highly efficient total synthesis of dictyodendrins A–E was accomplished. The synthesis features a novel benzyne‐mediated one‐pot indoline formation/cross‐coupling sequence for the construction of a highly substituted key indoline intermediate. Peripheral substituents were introduced onto this intermediate in a modular fashion to complete the total synthesis of dictyodendrins A–E.