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Two‐Photon Fluorescent Probes for Metal Ions
Author(s) -
Kim Hwan Myung,
Cho Bong Rae
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000542
Subject(s) - two photon excitation microscopy , context (archaeology) , nanotechnology , fluorescence , photon , intracellular , materials science , chemistry , biophysics , computer science , physics , biology , optics , biochemistry , paleontology
Abstract Two‐photon microscopy (TPM) has become an indispensible tool in biology and medicine owing to the capability of imaging the intact tissue for a long period of time. To make it a versatile tool in biology, a variety of two‐photon probes for specific applications are needed. In this context, many research groups are developing two‐photon probes for various applications. In this Focus Review, we summarize recent results on model studies and selected examples of two‐photon probes that can detect intracellular free metal ions in live cells and tissues to provide a guideline for the design of useful two‐photon probes for various in vivo imaging applications.