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1,4‐Diiodo‐1,3‐dienes: Versatile Reagents in Organic Synthesis
Author(s) -
Ananikov Valentine P.,
Hazipov Oleg V.,
Beletskaya Irina P.
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000405
Subject(s) - reagent , combinatorial chemistry , organic synthesis , chemistry , organic chemistry , computer science , catalysis
Abstract 1,4‐Diiodo‐1,3‐dienes are unique reagents in organic synthesis and have been employed in several well‐known and recently developed areas of application. Furthermore, these dienes are easily accessible, starting from the alkynes and iodine, and they have demonstrated high reactivity in cross‐coupling reactions, organometallic synthesis, in the preparation of heterocyclic compounds, and several other transformations . The high reactivity of the 1,4‐diiodo‐1,3‐dienes allows for the development of synthetic procedures that use mild conditions (room temperature). The key advantages in assembling complex organic molecules, natural products, and compounds for material science using 1,4‐diiodo‐1,3‐dienes as building blocks include high yields, excellent selectivity, and diverse reactivity in carboncarbon and carbonheteroatom bond formation. This Focus Review describes the scope and application of the 1,4‐diiodo‐1,3‐dienes in organic synthesis as well as summarizes the methods for preparation of the dienes.