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Ruthenium(III) Complexes of Macrocyclic Tertiary Amines Mediated NO Release from S ‐Nitrosothiols under in vitro and in vivo Conditions
Author(s) -
Ho ChiMing,
Leung HiuChi,
Lok ChunNam,
Che ChiMing
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000368
Subject(s) - in vivo , nitric oxide , in vitro , snap , ruthenium , chemistry , nitroso , stereochemistry , biophysics , biochemistry , medicinal chemistry , organic chemistry , biology , computer science , catalysis , computer graphics (images) , microbiology and biotechnology
There′s just NO SNAP! Ru III complexes of macrocyclic tertiary amines, especially trans ‐[Ru(14‐TMC)Cl 2 ]Cl ( 1 ), could mediate nitric oxide (NO) release from S ‐nitrosothiols in the presence of biological reductants. Interestingly, complex 1 was found to enhance rat aorta relaxation in the presence of S ‐nitroso‐ N ‐acetylpenicillamine (SNAP) under in vivo conditions.