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Highly Enantioselective Friedel–Crafts–type Alkylation Reactions of Indoles with Chalcone Derivatives using a Chiral Barium Catalyst
Author(s) -
Tsubogo Tetsu,
Kano Yuichiro,
Yamashita Yasuhiro,
Kobayashi Shū
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000347
Subject(s) - friedel–crafts reaction , alkylation , enantioselective synthesis , chalcone , catalysis , organic chemistry , chemistry , barium
Ba Ba black sheep : We have developed novel barium/binol catalysts prepared from alkaline earth metal amides and chiral binaphthol ligands. These catalysts effectively promoted the asymmetric Friedel–Crafts–type alkylation reactions of indoles with chalcone derivatives. This is the first example of asymmetric Friedel–Crafts–type alkylation reactions using chiral Brønsted bases.