Premium
Multicomponent Reactions for the Synthesis of Heterocycles
Author(s) -
Jiang Bo,
Rajale Trideep,
Wever Walter,
Tu ShuJiang,
Li Guigen
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000310
Subject(s) - domino , domino effect , computer science , biochemical engineering , reaction conditions , combinatorial chemistry , chemistry , process engineering , organic chemistry , engineering , catalysis , political science , law
Multicomponent domino reactions (MDRs) serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity, by a one‐pot operation. These reactions can dramatically reduce the generation of chemical wastes, costs of starting materials, and the use of energy and manpower. Moreover, the reaction period can be substantially shortened. This Review covers recent advances on multicomponent domino reactions for the construction of five‐, six‐, and seven‐membered heterocyclic skeletons and their multicyclic derivatives.