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Dethreading of Deoxyribonucleotides through α‐Cyclodextrin
Author(s) -
Kuzuya Akinori,
Ohnishi Toshiyuki,
Yamazaki Takahiro,
Komiyama Makoto
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000289
Subject(s) - deoxyribonucleotides , deoxyribonucleotide , cyclodextrin , chemistry , simple (philosophy) , process (computing) , computer science , combinatorial chemistry , chromatography , biochemistry , philosophy , nucleotide , epistemology , gene , operating system
Dethreading the needle! Rotaxanes of α‐cyclodextrin (CyD) capped by 1‐adamantaneacetic acid and a deoxyribonucleotide have been synthesized and purified with reverse‐phase (RP) HPLC. Thermodynamic parameters of the dethreading process of deoxyribonucleotides through α‐CyD were also successfully determined by simple and convenient kinetic study of the process using RP‐HPLC.