Premium
Cobalt‐Catalyzed Addition of Styrylboronic Acids to 2‐Vinylpyridine Derivatives
Author(s) -
Kobayashi Tsuneyuki,
Yorimitsu Hideki,
Oshima Koichiro
Publication year - 2011
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000275
Subject(s) - cobalt , catalysis , transmetalation , chemistry , nitrogen , nitrogen atom , base (topology) , organic chemistry , medicinal chemistry , polymer chemistry , group (periodic table) , mathematical analysis , mathematics
Abstract Treatment of 2‐vinyl nitrogen‐containing heteroaromatic compounds with styrylboronic acid in the presence of a cobalt catalyst and a base results in an addition reaction to afford the corresponding 4‐phenyl‐3‐butenyl heteroarenes. The adjacent nitrogen atom is essential for the promotion of the reaction because the nitrogen accelerates the addition of the styryl cobalt species, generated by transmetalation , onto the vinyl group. The reaction represents a rare example of cobalt catalysis in the reactions of organoboronic acids.