N  6 ‐(2‐( R )‐Propargylglycyl)lysine as a Clickable Pyrrolysine Mimic | Zendy

Li Xin | Zendy; Fekner Tomasz | Zendy; Chan Michael K. | Zendy

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N 6 ‐(2‐( R )‐Propargylglycyl)lysine as a Clickable Pyrrolysine Mimic

Author(s) -

Li Xin,

Fekner Tomasz,

Chan Michael K.

Publication year - 2010

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.201000205

Subject(s) - click chemistry , dipeptide , chemistry , azide , calmodulin , lysine , fluorescence , coumarin , combinatorial chemistry , yield (engineering) , bioorthogonal chemistry , copycat , biochemistry , amino acid , computer science , organic chemistry , enzyme , physics , quantum mechanics , materials science , artificial intelligence , metallurgy

Clickable copycat! Readily available dipeptide D ‐Pra‐ ε ‐Lys is identified using a modified fluorescence protein assay as a highly efficient clickable pyrrolysine mimic. It is shown to incorporate into calmodulin in high yield to provide a handle for labeling with an azide‐containing coumarin.

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