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Chemo‐ and Stereoselective Iron‐Catalyzed Hydrosilylation of Ketones
Author(s) -
Addis Daniele,
Shaikh Nadim,
Zhou Shaolin,
Das Shoubhik,
Junge Kathrin,
Beller Matthius
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000064
Subject(s) - hydrosilylation , stereoselectivity , catalysis , chemistry , organic chemistry
The reduction of ketones with polymethylhydrosiloxane (PMHS) gives the corresponding alcohols in good to excellent yield applying iron‐based catalyst systems. In the case of prochiral ketones, the use of Fe(OAc) 2 /( S,S )‐Me‐DuPhos leads to high enantioselectivity up to 99 % ee . The reaction proceeds in the presence of several functional groups such as esters, halides as well as conjugated double bonds, with high chemoselectivity. The advantage of this protocol is that the reaction requires no activating agents or additives.