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Asymmetric Catalytic Aziridination of Cyclic Enones
Author(s) -
De Vincentiis Francesco,
Bencivenni Giorgio,
Pesciaioli Fabio,
Mazzanti Andrea,
Bartoli Giuseppe,
Galzerano Patrizia,
Melchiorre Paolo
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000040
Subject(s) - indane , yield (engineering) , moiety , chemistry , catalysis , enantioselective synthesis , combinatorial chemistry , enantiomer , molecule , organic chemistry , materials science , metallurgy
The first catalytic method for the asymmetric aziridination of cyclic enones is described. The presented organocatalytic strategy is based on the use of an easily available organocatalyst that is able to convert a wide range of cyclic enones into the desired aziridines with very high enantiomeric purity and good chemical yield. Such a method may very well open up new opportunities to stereoselectively prepare complex chiral molecules that possess an indane moiety, a framework that is found in a large number of bioactive and pharmaceutically important molecules