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Synthesis and Characterization of 2‐(2′‐hydroxy‐5′‐chlorophenyl)‐6‐chloro‐4(3 H )‐Quinazolinone‐Based Fluorogenic Probes for Cellular Imaging of Monoamine Oxidases
Author(s) -
Aw Junxin,
Shao Qing,
Yang Yanmei,
Jiang Tingting,
Ang Chungyen,
Xing Bengang
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000025
Subject(s) - quinazolinone , monoamine neurotransmitter , oxidative deamination , tryptamines , chemistry , deamination , monoamine oxidase , fluorescence , primary (astronomy) , combinatorial chemistry , biochemistry , serotonin , enzyme , physics , receptor , tryptamine , quantum mechanics , astronomy
Monoamine oxidases (MAOs) catalyze the oxidative deamination of neurotransmitters and biogenic amines. A new class of activity‐based fluorescent probes based on the alkylation of 2‐(2′‐hydroxyphenyl)‐4(3 H )‐quinazolinone (HPQ) with primary, secondary, or tertiary amines is presented for real‐time imaging of MAO activity in living cells.