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Diastereo‐ and Enantioselective Organocatalytic Direct Conjugate Addition of γ‐Butenolide to Chalcones
Author(s) -
Zhang Yinan,
Yu Chenguang,
Ji Yafei,
Wang Wei
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000014
Subject(s) - butenolide , enantioselective synthesis , conjugate , thiourea , nucleophile , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , mathematics , mathematical analysis
A diastereo‐ and enantioselective conjugate addition reaction of γ‐butenolide with chalcones has been developed. Notably, unmodified γ‐butenolide was directly employed as a nucleophile in the Michael addition reactions. This process was catalyzed by a previously reported cyclohexane diamine thiourea under mild reaction conditions to afford enantioenriched synthetically and biologically important substituted furanones.