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Continuous Flow Organic Synthesis under High‐Temperature/Pressure Conditions
Author(s) -
Razzaq Tahseen,
Kappe C. Oliver
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201000010
Subject(s) - microreactor , flow chemistry , organic synthesis , process engineering , continuous flow , environmentally friendly , high pressure , flow (mathematics) , nanotechnology , process (computing) , computer science , environmental science , chemistry , materials science , biochemical engineering , engineering physics , engineering , organic chemistry , mechanics , physics , catalysis , ecology , biology , operating system
Microreactor technology and continuous flow processing in general are key features in making organic synthesis both more economical and environmentally friendly. When preformed under a high‐temperature/pressure process intensification regime many transformations originally not considered suitable for flow synthesis owing to long reaction times can be converted into high‐speed flow chemistry protocols that can operate at production‐scale quantities. This Focus Review summarizes the state of the art in high‐temperature/pressure microreactor technology and provides a survey of successful applications of this technique from the recent synthetic organic chemistry literature.