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New Approaches to the Total Synthesis of the Bryostatin Antitumor Macrolides
Author(s) -
Hale Karl J.,
Manaviazar Soraya
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900634
Subject(s) - total synthesis , bryostatin 1 , chemistry , stereochemistry , biochemistry , phosphorylation , protein kinase c
In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity . Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001–2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.