Premium
Aptamer–Target Binding Triggered Molecular Mediation of Singlet Oxygen Generation
Author(s) -
Tang Zhiwen,
Zhu Zhi,
Mallikaratchy Prabodhika,
Yang Ronghua,
Sefah Kwame,
Tan Weihong
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900545
Subject(s) - aptamer , singlet oxygen , photosensitizer , photodynamic therapy , chemistry , molecule , molecular oxygen , photochemistry , biophysics , selectivity , oxygen , combinatorial chemistry , biochemistry , catalysis , biology , microbiology and biotechnology , organic chemistry
Molecular mediation of singlet oxygen generation is demonstrated based on a newly engineered aptamer probe. Both ATP and human α‐thrombin aptamers were engineered to testify to this design, and both showed that the production of singlet oxygen can be triggered and quantitatively mediated by the presence of target molecules. Moreover, both photosensitizer aptamer switch (PAS) probes showed excellent selectivity toward their targets. These results suggest that a PAS can serve as a smart photodynamic therapy agent.