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Chiral Zirconium Complex as Brønsted Base Catalyst in Asymmetric Direct‐type Mannich Reactions
Author(s) -
Kobayashi Shū,
Salter Matthew M.,
Yamazaki Yumi,
Yamashita Yasuhiro
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900524
Subject(s) - zirconium , catalysis , brønsted–lowry acid–base theory , chemistry , base (topology) , mannich reaction , mannich base , enantioselective synthesis , polymer chemistry , organic chemistry , mathematics , mathematical analysis
Activating carbonyls : Asymmetric direct‐type Mannich reaction using a chiral zirconium complex as Brønsted base is demonstrated. Zirconium complexes prepared from Zr(O t Bu) and 3,3′‐disubstituted BINOL are found to be good catalysts in the reactions of an iminoester with malonates, and high enantioselectivities are obtained.