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Alternatives to Organoboron Reagents in Rhodium‐Catalyzed Conjugate Additions
Author(s) -
Hargrave Jonathan D.,
Allen Joseph C.,
Frost Christopher G.
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900512
Subject(s) - rhodium , transmetalation , stereocenter , reagent , chemistry , alkene , combinatorial chemistry , catalysis , conjugate , addition reaction , organic chemistry , stereoselectivity , organic synthesis , enantioselective synthesis , mathematical analysis , mathematics
The rhodium‐catalyzed conjugate addition of organoboron reagents to alkene acceptors has emerged as an important methodology in organic synthesis. The process results in the formation of new carbon–carbon bonds, and in principle, can create new stereocenters at both the α and β carbon atoms of the acceptor. Other organometallics are known to participate in the key transmetalation to rhodium and are becoming more established in stereoselective synthesis (notably arylzinc reagents). This Focus Review will describe recent developments in the use of alternative organometallic donors to organoboron reagents in rhodium‐catalyzed conjugate addition reactions and their growing applications in synthesis.