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Enantioselective Friedel–Crafts Alkylation of Indoles, Pyrroles, and Furans with Trifluoropyruvate Catalyzed by Chiral Phosphoric Acid
Author(s) -
Kashikura Wataru,
Itoh Junji,
Mori Keiji,
Akiyama Takahiko
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900481
Subject(s) - phosphoric acid , friedel–crafts reaction , enantioselective synthesis , alkylation , catalysis , adduct , organic chemistry , chemistry
Indoles, and pyrroles, and furans, oh my! Chiral phosphoric acid catalyzed Friedel–Crafts alkylation of indoles with 3,3,3‐trifluoropyruvate gave the corresponding adducts in excellent yields with high enantioselectivities. Electron‐deficient indoles, in particular, exhibited excellent enantioselectivities.
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