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Engineering Dendritic Aptamer Assemblies as Superior Inhibitors of Protein Function
Author(s) -
Kim Youngmi,
Dennis Donn M.,
Morey Tim,
Yang Liu,
Tan Weihong
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900421
Subject(s) - aptamer , dendrimer , molecular recognition , nucleic acid , function (biology) , small molecule , chemistry , computational biology , dna , branching (polymer chemistry) , oligonucleotide , nanotechnology , molecular binding , combinatorial chemistry , epitope , biophysics , molecule , biochemistry , biology , microbiology and biotechnology , materials science , antibody , genetics , organic chemistry
Branching out : A new method has been developed for designing superior inhibitors of protein function by assembling heterogeneous aptamers into dendritic aptamer assemblies composed of two different functional domains: an anchor and a dendrimer‐like inhibitor (27Apt and 15Apt, respectively). The engineering of this heterogeneous ligand assembly enhances molecular function for thrombin binding, and provides novel advantages and further improves inhibitory efficacy.