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Pyridyl‐Substituted Corrole Isomers: Synthesis and their Regulation to G‐quadruplex Structures
Author(s) -
Ma Heng,
Zhang Ming,
Zhang Dan,
Huang Rong,
Zhao Yang,
Yang Hao,
Liu Yijing,
Weng Xiaocheng,
Zhou Yangyang,
Deng Minggang,
Xu Liang,
Zhou Xiang
Publication year - 2010
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900270
Subject(s) - g quadruplex , telomere , dna , corrole , surface plasmon resonance , chemistry , polymerase , computational biology , gene , stereochemistry , combinatorial chemistry , biology , biochemistry , nanotechnology , photochemistry , materials science , nanoparticle
G‐quadruplex DNA plays an important role in the potential therapeutic target for the design and development of anticancer drugs. As various G‐quadruplex sequences in the promoter regions or telomeres can form different secondary structural modes and display a diversity of biology functions, variant G‐quadruplex interactive agents may be necessary to cure different disease by differentiating variant types of G‐quadruplexes. We synthesize five cationic methylpyridylium corroles and compare the interactions of corroles with different types of G‐quadruplexes such as cmyc, htelo, and bcl2 by using surface plasmon resonance. Because of the importance of human telomere G‐quadruplex DNA, we focus on the biological properties of the interactions between human telomere G‐quadruplex DNA and corrole isomers using CD, T m , PCR‐stop (PCR= polymerase chain reaction ), and polymerase‐stop assay, which demonstrate the excellent ability of the corrole to induce and stabilize the G‐quadruplex. This study provides the first experimental insight into how selectivity might be achieved for different G‐quadruplexes by a single group of methylpyridylium corrole isomers that may be optimized for potential selective cancer therapy .