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Direct Oxidation of β‐Aryl Substituted Aldehydes to α,β‐Unsaturated Aldehydes Promoted by an o ‐Anisidine–Pd(OAc) 2 Co‐catalyst
Author(s) -
Liu Jie,
Zhu Jin,
Jiang Hualiang,
Wang Wei,
Li Jian
Publication year - 2009
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900238
Subject(s) - catalysis , enol , aryl , chemistry , silylation , oxidation process , organic chemistry , medicinal chemistry , process (computing) , chemical engineering , computer science , alkyl , engineering , operating system
An o ‐anisidine‐Pd(OAc) 2 catalytic system for the direct co‐catalytic Saegusa oxidation of β‐aryl substituted aldehydes to α,β‐unsaturated aldehydes has been developed. The use of o ‐anisidine in place of ( S )‐diphenylprolinol made the process more simply and cost‐effective. The process not only features the use of unmodified aldehydes rather than enol silyl ethers, but also gives moderate to good yields (44–72 %).