Premium
A DBFOX‐Ph‐Based Combinatorial Catalyst for Enantioselective Fluorination of Aryl Acetyl and 3‐Butenoyl Thiazolidinones
Author(s) -
Reddy Dhande Sudhakar,
Shibata Norio,
Horikawa Takao,
Suzuki Satoru,
Nakamura Shuichi,
Toru Takeshi,
Shiro Motoo
Publication year - 2009
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900164
Subject(s) - enantioselective synthesis , aryl , catalysis , combinatorial chemistry , chemistry , combinatorial synthesis , organic chemistry , alkyl
The catalytic asymmetric fluorination for aryl acetyl and 3‐butenoyl thiazolidinones was achieved with extremely high enantioselectivity by the use of a combinatorial catalyst, DBFOX‐Ph/Ni II /HFIP/2,6‐lutidine, and provides an effective entry to chiral α‐fluorinated compounds. The combinatorial catalyst system is also applicable to the first enantioselective α‐chlorination of aryl acetyl thiazolidinones.