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Palladium‐Catalyzed ( N ‐Oxido‐2‐pyridinyl)methyl Transfer from 2‐(2‐Hydroxyalkyl)pyridine N ‐Oxide to Aryl Halides by β‐Carbon Elimination
Author(s) -
Suehiro Takafumi,
Niwa Takashi,
Yorimitsu Hideki,
Oshima Koichiro
Publication year - 2009
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200900151
Subject(s) - palladium , halide , aryl , chemistry , catalysis , pyridine , pyridine n oxide , medicinal chemistry , oxide , organic chemistry , alkyl
Successful transfer application : ( N ‐Oxido‐2‐pyridinyl)methyl transfer from (2‐hydroxyalkyl)pyridine N ‐oxide derivatives to aryl bromides proceeds under palladium catalysis through β‐carbon elimination involving cleavage of an unstrained C(sp 3 )C(sp 3 ) bond, yielding 2‐benzylpyridine N ‐oxide derivatives.
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