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Cover Picture: The Synthesis of D ‐Trihydroxyllysine‐Based Oligopeptides as a Hydrophilic Scaffold and its Application to the Synthesis of Bifunctional Chelating Agents for Use as Bone Tracers (Chem. Asian J. 12/2008)
Author(s) -
Tanaka Hiroshi,
Ando Yoshio,
Abe Tsutomu,
Takahashi Takashi
Publication year - 2008
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.200890038
Subject(s) - bifunctional , bisphosphonate , oligopeptide , scaffold , chemistry , chelation , combinatorial chemistry , in vivo , diphosphonates , organic chemistry , biochemistry , computer science , peptide , osteoporosis , bone resorption , medicine , database , biology , microbiology and biotechnology , endocrinology , catalysis
Bone tracers made by using an effective hydrophilic scaffold composed of D ‐trihydroxyllysine‐based oligopeptides and its application in the synthesis of the various 111 In–DTPA conjugates with mono‐ to penta‐bisphosphonate units is described. H. Tanaka, T. Takahashi et al. show that none of the 111 In III complexes investigated show any significant toxicity or degradation in vivo and two of these complexes are suitable for use as bone tracers. This research introduces a good building block for the synthesis of multivalent ligands applicable to medical use. For more information, see their Full Paper on page 2033 ff.